The Quadruple Down Syndrome Test

16 to 22 weeks

The Quadruple Test is a screening for Down Syndrome and is usually performed if you have missed the Nuchal Scan earlier in your pregnancy.

In addition the test can also alert for those at higher risk of Spina Bifida.

Like the Nuchal Scan the Quadruple Test is a screening test, which means it cannot tell us if your baby has Down Syndrome, instead it tells us if your baby is at a greater risk of having the condition.

Why is it called the Quadruple Test?
It is called the Quadruple Test because it measures four substances in your blood:

• AFP
• Beta HCG
• Inhibin-A
• Oestriol

How is the test performed?
The test is blood test so we will need to take a sample.

Before taking the blood sample you must have a scan to accurately date your pregnancy.

If we have not scanned you previously in this pregnancy we will perform a scan first, otherwise we can use information saved on our Fetal Database from your prior appointment.

What other information is required?
We also need to know the following details to accurately perform the test:

• First day of last Menstrual Period? (LMP)
• Maternal Weight? (we have scales)
• Ethnic Origin of the Mother?
• Are you Insulin Dependent?
• Date of Birth for donor? (If an IVF pregnancy)
• Are you a smoker?
• Are you taking Folic Acid?

When will I get the results?
Your blood sample is sent to the laboratory and we usually receive the result in 4 working days.

We will call you with the outcome of the test and forward a hard copy of the report to you and your GP, Midwife or Obstetrician.

In the report you will receive a risk estimate similar to the screening performed at the Combined Test.

If you and your partner are not reassured by the final risk estimate you have the option of having an Amniocentesis at The London Ultrasound Centre to obtain a definite result.

What are the risks?
The test is not dangerous and will not harm you or your baby.

Are there any limitations to the test?
The Quadruple Test can only be performed between 16 and 22 weeks of your pregnancy.

The Quadruple Test cannot be performed if you are an insulin dependent diabetic.

The Quadruple Test cannot be performed on twins

What's the alternative?
An alternative is to have a detailed scan performed by one of our highly qualified Consultants or Sonographers around the middle of your pregnancy where they will look for 'markers' for Down Syndrome and Spina Bifida.

To obtain an absolute answer you may decide to have the Amniocentesis diagnostic test.

How do I book?
For bookings information and prices please see our Prices page.